STUDIES ON THE CHEMOTHERAPY OF LEPROSY (Report 20)

FURTHER STUDIES ON THE SUPPRESSION OF ONSET MURINE LEPROSY BY NON-CHEMICAL AGENTS AS CHAULMOOGRA OIL AND TRITON AND ANTI-BIOTICS

Abstract

Triton, Taifumin A, Minophagen AT, Chaulmoogra oil and olive oil were experimentally administered for 150 days in experimentally infected murine leprosy mice but proved ineffective.
Chaulmoogra oil was ineffective in mice but an effect was apparent in the rat. Similar results had been obtained in the rat in a series of studies conducted in 1942. From this finding, it is suggested that rats rather than mice should be used in experiments with non-chemical agents as Chaulmoogra oil.
Of the antibiotics examined, Dextromycin clearly suppressed onset but Acidomycin was without effect.