HISTOPATHOLOGICAL STUDIES ON HUMAN LEPROSY
V. HISTOPATHOLOGICAL CHANGES IN THE LYMPHNODES OF CHAULMOOGRA OIL ADMINISTERED HUMANS AND DOGS
1958 Volume 27 Issue 5 Pages 383-393
Details
1958 Volume 27 Issue 5 Pages 383-393
The histopathological changes in the lymphnodes of dogs injected intramuscularly with Chaulmoogra oil were investigated and the findings compared to those in man.
1) The intramuscularly injected Chaulmoogra oil was deposited in the regional lymphnodes and giant vacuoles and foreign body giant cells similar to those seen in the lymphnodes of the extremities in human leprosy were found.
2) A part of the Chaulmoogra oil administered by mouth is deposited in the mesen-teric lymphnode system.
3) Lipoidemia occurs by both routes of administration and the lymphnodes through-out the body and the reticuloendothelial systems of the spleen and liver show a form of lipoidhistiocytosis. Granuloma formation however, was not observed.
4) There was an increase in fat loading of the erythrocytes and activation of the reticuloendothelial system with a marked increase in red cells and haemosiderin of the reticuloendothelial system.
