Abstract
Mice were inoculated with murine leprosy bacilli (Hawaiian strain) and the protein, lipoprotein and polysaccharide fractions of the serum studied by paper electrophoresis. The following results were obtained.
1) Serum protein fraction : From about the 16 th week after infection, *-globulin increased and albumin decreased. When divided into the leproma group and the ulcer formation group this finding was more marked in the latter. In the group in which leproma could not be observed macroscopically, that is, the "spontaneous cure" group, the values were close to normal. From about 10 months after infection, an increase in a-globulin was found and there was a marked increase in the ulcer group at 12.5 months.
2) Serum lipoprotein fraction : A marked increase in a-lipoprotein was found in both liproma and ulcer groups but the pattern differed slightly between the two. This finding is present 10 months after infection.
3) Serum protein-bound polysaccharide fraction : A marked increase in *-polysac-charide was found after 7 months in the ulcer group but there was no marked increase in the leproma group.
