ANALYTICAL STUDIES ON ANTILEPROUS DRUGS

I. BASIC ANALYTICAL METHODS FOR THE INVESTIGATION OF THE METABOLITES OF 4, 4'-DIAMINODIPHENYLSULFOXIDE (DDSO) IN VIVO

Abstract

In order to investigate the metabolism of sulfoxide radical of DDSO by in vivo oxido- reduction system, this author attempted the separation of DDS, DDSO, and 4, 4'-Diaminodiphe- nylsulfide (DDSD) by the use of paper chromatography and paper electrophoretic method.
As the result of this investigation, a basic analytical method was found, when DDSO was used alone, which enables the separation of those three compounds by certain combi- nations of buffer chromatography and paper electrophoresis.