STUDIES ON ANTIMYCOBACTERIAL SUBSTANCES

II. ON POLYETHYLENE GLYCOL E THANE SULFONATES OF P-MONOACY LAMINO-P'-AMINO-DIPHENYLSULFONE

Abstract

It has been known that the antituberculous activity of certain polyethylene glycol deri-vatives of DDS was stronger than that of DDS itself, and that Triton WR 1339, a surface active agent having a polyethylene glycol group in the molecule, was effective in the treatment of experimental tuberculosis of animals. On the other hand, when a carbon chain such as acyl group is introduced into the molecule, compounds with a certain specific carbon number of the carbon chain thus formed are generally increased of physiological activities including antimicrobial action. Enhancement of the antimicrobial action is que-stionable in the chemotherapy of leprosy, but experiments were undertaken from the views above mentioned. Polyethylene glycol ethane sulfonates of p-monoacylamino-p'-amino-diphe nylsulfone were synthesized to determine their in vitro antimicrobial activities, and thus to obtain some basic informations for their clinical applicability. None of the compounds employed in the present experiments were found to have antimicrobial activities stronger than DDS itself.