Studies on Antileprotic Agents (No. 6)
The pharmacological action of 4-amino-4'-aldehydethiosemicarbazone- diphenylsulfone (Thiozamin)
1965 Volume 34 Issue 1 Pages 1-6
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1965 Volume 34 Issue 1 Pages 1-6
Since the discovery of antileprotic agents like "Promin" interest has been stimulated in the study of other antibiotics and synthetic compounds (sulfone and thiourea derivertives) in regard to their antileprotic activity. Studies of the synthesis and antibacterial action of the new compound were made, has been published in "Studies on antileprotic agents, report No. 3".*
Structure of the compound is as follows and the term of this compound will given as "Thiozamin" in this paper.
NH2- -SO2 - -CH=N NH CS NH2
The present auther has accordingly examined on the pharmacological actions of Thiozamin and has got the following results.
1. The suspension of Thiozamin was administered subcutaneously to mice. LD50……1705.5mg/kg=
2. No hemolytic action.
3. No change of respiratory action and blood pressure even with such a large dose.
4. Actions on the intestine of the rabbit caused spasmogenic activity in very little dose and decreased in the tone of intestine were used large.
From the results described above, it will be possible to the drug for a treatment of leprosy.
