Effect of DDS-administration on the Multiplication of M. leprae in the Mouse Foot-pads
1968 Volume 37 Issue 3 Pages 235-238
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1968 Volume 37 Issue 3 Pages 235-238
The inhibitory effect of DDS upon the multiplication of M. leprae was tested in the mouse foot-pads.
Multiplication of the so-called resistant strains (Fuji, Urashima) were suppressed completely by DDS in the higher dosages containing 0.5mg in the diet of one gram. However, even the sensitive strain (no growth in 0.1mg) was not suppressed completely in case of DDS-administration which was given from the time of 3 months after inoculation.
On the other hand, DDS-administration to the moderately resistant strain in the mouse foot-pad (growth in 0.1mg) was continued in a period of about 17 months, but it resulted that the growth of the bacilli was not completely suppressed.
