Abstract
Based on the observation that the secondary dapsone resistant patients were more refractory to treatment with rifampicin, the clinically suspected dapsone resistant cases were screened for rifampicin resistance. By mouse foot-pad technique it was found that out of five multibacillary types of leprosy patients who had irregular monotherapy with dapsone for varying periods, three patients were resistant to dapsone. Subsequently these dapsone resistant patients were also found to be resistant to rifampicin.
