Dapsoneおよびリファンピシンによる少数菌らい患者の治療

N.M. SAMUEL; S. SAMUEL; R.B. ADIGA

doi:10.5025/hansen1977.54.193

Treatment of Paucibacillary Leprosy Patients with Dapsone and Rif ampicin

N.M. SAMUEL, S. SAMUEL, R.B. ADIGA

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JOURNAL FREE ACCESS

1985 Volume 54 Issue 4 Pages 193-197

DOI https://doi.org/10.5025/hansen1977.54.193

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Published: December 30, 1985 Received: September 02, 1985 Available on J-STAGE: February 26, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: February 26, 2008 Reason for correction: - Correction: DTRECEIVED Details: Right : 19850902

Date of correction: February 26, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Dapsone resistance is found worldwide(1, 2) and resistance to other available drugs such as clofazamine(3) and rifampicin(4) also occurs. It is known that paucibacillary leprosy patients harbour<106 bacilli(5). However, the treatment of paucibacillary leprosy is of long duration. It is psychologically undesirable for a symptom-free, paucibacillary patient to receive therapy for a long period of time(6). In practice, many patients discontinue treatment prematurely although they may continue to attend the treatment services. The high failure rate of standard dapsone therapy in control programmes in the developing countries stems directly from the difficulty of persuading patients to remain under treatment for long enough(7).
Concerned at the problem of high patient failure rate and high relapse rates in Nepal, we have instituted short course multidrug thercpy (MDT) for leprosy in 1981. Administration of one dose of rifampicin every month was supervised. In this article, we review the progress made
Right : Five hundred and ninety paucibacillary patients were administered multidrugtherapy since 1981. Except for 22, all patients were regular for treatement. Thirty-two pateints developed complications during therapy. All patients responded well to treatement. In the smear positive group, the regression of the lesions was relatively slow and the lesions persisted for longer. Patients were followed up for 28 months. At 18 months of post-MDT follow up, 13% of smear positive patients and 9 % of smear negative patients relapsed. An overall relapse rate was 10%.

Date of correction: February 26, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: February 26, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Five hundred and ninety paucibacillary patients were administered multidrugtherapy since 1981. Except for 22, all patients were regular for treatement. Thirty-two pateints developed complications during therapy. All patients responded well to treatement. In the smear positive group, the regression of the lesions was relatively slow and the lesions persisted for longer. Patients were followed up for 28 months. At 18 months of post-MDT follow up, 13% of smear positive patients and 9 % of smear negative patients relapsed. An overall relapse rate was 10%.

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