Abstract
We evaluated frontal lobe functions using functional magnetic resonance imaging in patients with diffuse axonal injury. The findings demonstrated increase of activity (1) in bilateral dorsolateral prefrontal regions during the auditory serial addition test, (2) in bilateral posterior parietal regions during the effortful learning task, and (3) dorsomedial prefrontal regions during the self- knowledge task. These findings may mean compensatory activity of cortex during recovery stage after diffuse axonal injury. Since correlation between cortical activities and performance is not consistent, we must be careful to interpret meaning of cortical activities especially during the recovery stage.
