Evolution of TRUMP^® as a Transplant and Cellular Therapy Registry

Abstract

 A hematopoietic cell transplantation (HCT) registry serves as a database for grasping HCT activity in Japan. Registry data contributes to retrospective observational research activity. In January 2020, TRUMP^® version 2.4, a Web database developed for the purpose of centralized online management of HCT outcome data, was released after a major revision of survey items. After the launch of a genetically modified T cell (CAR-T) therapy product, three HCT registries (CIBMTR, EBMT, and JSHCT/JDCHCT) harmonized survey items for cellular therapy. Thus, these HCT registries developed into HCT and cellular therapy registries. In March 2020, JSHCT/JDCHCT launched the Japanese version of FormsNet3 for their cellular therapy outcome registry based on the revised JSHCT/JDCHCT HCT and Cellular Therapy registry protocol. This cellular therapy registry enables the collection of outcome data for cellular therapy, including multiple CAR-T products, on the same platform with compatibility across registries. The activity will lead to a better outcome research platform for HCT and cellular therapy.