Abstract
Some studies have reported the graft versus tumor (GVT) effect against neuroblastoma, but it remains unclear whether this effect is associated with long-term survival in neuroblastoma. Here, we describe a 13-year-old boy who has survived for 7 years following allogeneic hematopoietic stem cell transplantation (HSCT) for refractory neuroblastoma. The patient received conventional therapy, but there were residual tumor cells in bone marrow. Hence, he received allogeneic HSCT. Although he did not achieve complete remission just after HSCT, tumor markers were reduced during severe chronic graft versus host disease (cGVHD). This indicates the possibility that the GVT effect against neuroblastoma is associated with cGVHD and it can improve long-term outcome.
