2018 Volume 7 Issue 2 Pages 40-48
The most significant obstacle hindering the improvement of transplant outcomes is death by transplant-related complications such as graft-versus-host disease, infection, or organ dysfunction. Severe veno-occlusive diseases or thrombotic microangiopathy in particular are causes of high mortality, and endothelial damage by thrombosis is a common cause of these complications. To reduce organ dysfunction, we administered danaparoid, an anticoagulant with high antiⅩa/antiⅡa activity, and found that transplant-related mortality was significantly decreased. As for late effects after transplantation, sterility was attenuated by elimination or reduction of busulfan, or total body irradiation. Overall, in order to reduce transplant-related early or late complications, it is important to improve supportive therapy or reduce the intensity of the conditioning regimen without increasing the relapse rate in malignant disorders.
