Abstract
Complications associated with allogenic hematopoietic stem cell transplantation include oral mucosal disorder and severe sepsis resulting from myelosuppression. The present study investigated factors that could potentially suppress severe oral mucosal disorder during allogeneic hematopoietic stem cell transplantation. A survey was conducted of patients who received allogenic hematopoietic stem cell transplantation between April 2011 and March 2015. Survey items included age, sex, stem cell source, Hematopoietic Cell Transplantation-specific Comorbidity Index score, human leukocyte antigen compliance, the intensity conditioning regimen, total body irradiation dose, methotrexate administration, oral management (2013.4-), myelosuppression of hematopoietic stem cell transplantation, and professional mechanical tooth cleaning (PMTC) before hematopoietic stem cell transplantation. Age (P=0.0560) was associated with the severity of oral mucosal disorder (P<0.2), and PMTC before hematopoietic stem cell transplantation (P=0.0021) was selected. In logistic regression analysis, PMTC before hematopoietic stem cell transplantation was significantly associated with reduced severe oral mucosal disorder (odds ratio 0.3692; P=0.0017). We examined the cases without PMTC or PMTC after August 2012 when there was myelosuppression before July 2017 and found significant oral mucosal disorder in the group treated with PMTC had been reduced (P=0.0024). PMTC is an important supportive therapy to suppress the severe oral mucosal disorder suggested that it should be performed for all patients before undergoing allogenic hematopoietic stem cell transplantation.
