Abstract
Resorcinol cyclic tetramer (n-Host) interacts with polar organic compounds such assugars, alcohols and carboxylic acids via multiple hydrogen-bonding. The host also extractsniacins from its water solution to a nonpolar organic solvent via same manner. Niacins used arenicotinamide, isonicotinamide, picolinamide, nitcotinic acid, isonicotinic acid, and nicotinamidederivative compounds. Extraction rate of niacins increases in order of affinity of host-guestinteraction. Especially, n-Host interacts strongly with nicotinamide via double hydrogen-bondinginteraction, because amide group and N-atom on pyridine of nicotinamide are able to interactconveniently with binding-sites of n-Host. On the contrary, n-Host interacts weakly withisonicotinamide, because amide group and N-atom on pyridine aren't able to interact simultaneouslywith n-Host.
