Development of Analytical System for Radiocarbon Determination in Biomedical Sample by Cavity Ring-down Spectroscopy

Abstract

  The radioactive isotope ¹⁴C is utilized for carbon dating and as a tracer in the environment or human body. In drug development, a new clinical trial using a limited amount of ¹⁴C called “Microdose study” has been developed to directly investigate pharmacokinetics in the human body. While Accelerator Mass Spectrometry has extremely high sensitivity above natural abundance, its high cost and less throughput are insufficient for this purpose. In this study, we are developing alternative method for ¹⁴C analysis based on mid infrared Cavity Ring-Down Spectroscopy (CRDS) toward Microdose study.