Abstract
We studied the effect of a rat renin inhibitory peptide (RRIP) on kidney renin synthesis in spontaneously hypertensive rats (SHR). The RRIP was intraperitoneally administered (n=6) via an osmotic minipump to 11-week-old SHR for 7 days, at a rate of 10μg/kg/min. RRIP significantly reduced PRA and suppressed the elevation of systolic blood pressure in treated SHR compared to control. The content of kidney renin messenger RNA (mRNA) in treated SHR was comparable to that of control. Electron microscopic study revealed many renin granules and renin protogranules containing crystalline matrices in juxtaglomerular cells in RRIP-treated SHR. These results suggest that RRIP does not stimulate or suppress renin synthesis in the kidney. (Hypertens Res 1992; 15: 99-104)
