Role of Glycosaminoglycans in Vascular Disease with Risk of Thrombosis

Jorge A. Sison, MD, FPCC

doi:10.14911/ibr.2004.0.23.0

Proceedings 2004 of the 3rd Joint International Congress on Disability and Biophilia Rehabilitation Conference

Session ID : Invited 07

DOI https://doi.org/10.14911/ibr.2004.0.23.0

Conference information

Host: Biophilia Rehabilitation Academy

Co-host: Medical Center Manila, Northern Marianas College

Role of Glycosaminoglycans in Vascular Disease with Risk of Thrombosis

*Jorge A. Sison, MD, FPCC

Author information

Keywords: Glycosaminoglycans, sulodexide, micro- and macrovasculopathy in diabetes

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Glycosaminoglycans (GAGs) which are synthesized by the endothelium are normal constituents of the vessel wall that maintains electronegativity. This is important to maintain the endothelium protected from platelets, leukocytes and other toxic molecules. The vessel wall selective permeability status is also maintained by GAGs. In the bloodstream, circulating GAGs has an anti-platelet effect by inhibiting thrombin and cathepsin-G enzyme released by leukocytes.

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