IEEJ Transactions on Electronics, Information and Systems
Online ISSN : 1348-8155
Print ISSN : 0385-4221
ISSN-L : 0385-4221
Special Issue Review
Systemic Modeling of Biological Functions in Consideration of Physiome Project
—A Neural Network Model of Pain Conduction System and Mathematical Analysis of Pain Sensation—
Haruyuki Minamitani
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2007 Volume 127 Issue 10 Pages 1478-1485

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Abstract
Emerging of the physiome project provides various influences on the medical, biological and pharmaceutical development. In this paper, as an example of physiome research, neural network model analysis providing the conduction mechanisms of pain and tactile sensations was presented, and the functional relations between neural activities of the network cells and stimulus intensity applied on the peripheral receptive fields were described. The modeling presented here is based on the various assumptions made by the results of physiological and anatomical studies reported in the literature. The functional activities of spinothalamic and thalamocortical cells show a good agreement with the physiological and psychophysical functions of somatosensory system that are very instructive for covering the gap between physiologically and psychophysically aspects of pain and tactile sensation.
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© 2007 by the Institute of Electrical Engineers of Japan
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