Relationship between Red Blood Cell Aggregation Degree and Peak Frequency of Ultrasonic Reflection Spectrum in Porcine Blood

Abstract

For the subject to actualize a noninvasive and continuous monitoring technique of blood viscosity, we had demonstrated that the peak frequency of the ultrasonic reflection spectrum was an effective index by using red blood cell-mimicking particles. The reasons for using the particles were (i) the control difficulty of the aggregation degree, which had a strong correlation with the blood viscosity, and (ii) the weak reflection coefficient of the red blood cells in the plasma. In this paper, a possibility of the quantitative control of the red blood cell aggregation and an agreement between the aggregation degree and the peak frequency obtained using the actual porcine blood are described.