IEEJ Transactions on Electronics, Information and Systems
Online ISSN : 1348-8155
Print ISSN : 0385-4221
ISSN-L : 0385-4221
<Biomedical Engineering>
Effect of Magnetic Nanoparticle Internalization on Cell Density in Skeletal Muscle Tissue
Yuji KiriharaHiromu MiyataZugui PengKenta ShimbaYoshitaka MiyamotoKazunori ShimizuHiroyuki HondaTohru Yagi
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2021 Volume 141 Issue 7 Pages 795-801

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Abstract

The engineering of skeletal muscle tissue has gained considerable attention in recent years because of its clinical applications, which include muscle replacement and treatment of muscle-related disease. Magnetic nanoparticle internalization by skeletal muscle cells has been proposed as a means of improving cell density. In this study, by embedding magnetic nanoparticles in mouse C2C12 myoblast cells to engineer a muscle tissue sheet, we evaluated the cellular uptake of magnetic nanoparticles and their effects on cell proliferation and differentiation. Our results show a tendency for decreased muscle fiber thickness in C2C12 cells with internalized magnetite nanoparticles. However, no change was found in the number of cells or differentiation.

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© 2021 by the Institute of Electrical Engineers of Japan
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