Abstract
Since treatment at present does not consider the circadian variation of blood pressure in patients, adverse reactions such as over reduction of blood pressure by drug administration and the harm not to reduce blood pressure still remain. There are few researches to analyze quantitatively by employing a mathematical model. It is important that a mathematical model is contracted to treat hypertension quantitatively. In this paper, the submodel for endocrine system is proposed employing biochemical substances which regulate mean blood pressure. The submodel for autonomic nervous system is proposed. And a model for mean blood pressure is proposed employing the submodel for endocrine system and the submodel for autonomic nervous system. The method that decides the parameters in the model for mean blood pressure was discussed. The circadian variation of heart rate and mean blood pressure was estimated using the presented model. Absolute error between estimated results and measured results was discussed.
