Molecular mechanism for the structural diversity in natural products synthesized by amino-group carrier protein-mediated biosynthetic system

Abstract

In a thermophilic bacterium, Thermus thermophilus, lysine was found to be biosynthesized using a novel carrier protein (amino-group carrier protein: AmCP). It has been becoming clear that AmCP system is used for the biosynthesis of non-proteinogenic amino acids in various bacteria, including actinomycetes. In this study, we searched for novel natural products synthesized from non-proteinogenic amino acids that are biosynthesized through the AmCP system, and analyzed the biosynthetic pathways and mechanisms to expand the structural diversity of natural products.