The Short-Term Effects of Chondroitin Sulfates A and C on Coronary Atherosclerotic Subjects

With Reference to Its Anti-Thrombogenic Activities

Abstract

Effects of a single intravenous injection of chondroitin sulfates A and C on coronary atherosclerotic subjects were studied by using an electrocardiogram and measuring thrombus-formation time and prothrombin time. Improvement of ST and T changes after a single intravenous injection of chondroitin sulfate C was observed in coronary atherosclerotic patients with electrocardiographically appreciable ST depression, being associated with the prolongations of thrombus-formation time and of prothrombin time. These effects were more active in chondroitin sulfate C than in chondroitin sulfate A. Possible ameliorating effects of chondroitin sulfates A and C on coronary atherosclerosis were discussed in relation with their anti-thrombogenic properties.