Abstract
An activity of prostaglandin (PG)-like substances was measured in venous blood and renal medullary tissue of dogs. The PG-like substances were extracted by silica gel column chromatography and their activity was measured by rat vasodepressor bioassay. The activity of PGE-like substance both in renal venous blood and medulla was greater in saline infused dogs than in control, non-infused dogs. The possibility was discussed that the increased activity of PGE in kidney may be involved in the mechanisms of natriuresis in saline-loaded animals.
