A Study on the Effects of Nifedipine in Hypertensive Crises and Severe Hypertension

Iwao KUWAJIMA; Keiji UEDA; Chizuko KAMATA; Satoru MATSUSHITA; Kizuku KURAMOTO; Mototaka MURAKAMI; Yoshiyuki HADA

doi:10.1536/ihj.19.455

Iwao KUWAJIMA, Keiji UEDA, Chizuko KAMATA, Satoru MATSUSHITA, Kizuku KURAMOTO, Mototaka MURAKAMI, Yoshiyuki HADA

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Keywords: Ca⁺⁺ antagonists, Hemodynamics in hypertension, Left ventricular dimension on echocardiogram, Hypertensive emergency, Intractable hypertension

JOURNAL FREE ACCESS

1978 Volume 19 Issue 4 Pages 455-467

DOI https://doi.org/10.1536/ihj.19.455

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Abstract

Ten mg of Nifedipine, a Ca⁺⁺ antagonist, was administered orally in 2 groups of patients; Group I: 6 patients in hypertensive emergency and Group II: 12 patients with intractable, severe hypertension. Following results were obtained. 1) A marked hypotensive effect was observed in all patients of Group I. The maximum effect was observed within 30 to 60min and lasted for approximately 180min. Clinical symptoms also improved remarkably with the fall in blood pressure. Any side effect was not observed. 2) A marked hypotensive effect was observed in all cases of Group II. The blood pressure fell by 21.4% systclic (p<0.01) and 19.4% diastolic (p<0.02). The peripheral vascular resistance also showed the decrease by 26.2% (p<0.01). The heart rate and cardiac index increased slightly.
It was suggested that the hypotensive mechanism of this preparation is due primarily to the peripheral vasodilatation.

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