Mechanisms Underlying Systemic Hemodynamic Responses to Experimental Coronary Artery Occlusion

A Preliminary Study with Hexamethonium

Abstract

The hemodynamic changes induced by coronary occlusion were investigated in anesthetized dogs. Coronary occlusion elicited an immediate but transient increase in the systemic blood pressure and in the vascular resistance of the hind limb perfused at constant flow. Thereafter, systemic hypotension and vasodilatation in the perfused region were observed. Vagotomy abolished the initial increase of the systemic and perfusion pressure and reduced significantly the late vasodilator response both systemically and in the perfused hind limb. After the subsequent administration of hexamethonium the vasodilatation in the hind limb was no longer manifest but the fall in blood pressure was unmodified.
These results seem to suggest that multiple mechanisms are involved in the hemodynamic response to coronary occlusion.