Abstract
Hydralazine and α-methyldopa administered per os, did not significantly lowered the blood pressure of SHRSP rats, in the 8, 16 and 24 week-old SHRSP in the doses used in this study.
In group of 40 week-old SHRSP, both of the drugs did not lowered the blood pressure. However, the narrowing of the retinal arterioles was less progressive in the treated groups of SHRSP than in the untreated SHRSP.
These findings may suggest that sclerotic alterations of the retinal arteriolar wall caused by long duration of hypertension are prevented by vasodilative agents such as hydralazine and α-methyldopa.
