Abstract
Experimental results demonstrate that allogeneic thymus graft completely restored the immune functions in the T-cell depressed SHR as detected by a rosette forming test, plaque forming assay and blastogenesis, and lowered titers of NTA in the serum of SHR. Injection of TS had less effects to immune functions and NTA titers. The relationship between T-cell depression and hypertension of SHR is not clear yet. However, allogeneic thymus grafts significantly suppressed hypertension of SHR from 2 weeks after grafts. Injections of TS prevented the development of hypertension in SHR. These results suggest that immunological abnormality may be related to development of hypertension in SHR.
