Effect of Atherogenesis on Membrane Lipid Constituents of Rabbit Erythrocytes

Abstract

Lipids from erythrocyte membranes of normal and cholesterol fed animals were isolated and the various fractions were analyzed quantitatively. Erythrocyte membrane lipid composition of animals fed with an atherogenic diet for 2 months revealed marked elevations in cholesterol followed by significant alterations in phospholipids, free fatty acids and triglycerides. These findngs were discussed from the point of view of the role of membrane lipids in the maintenance of cell integrity, shape, and homeostasis.