An extracorporeal bypass was performed in mongrel dogs for 2 hours with or without hypertonic mannitol infusions. In animals given mannitol, the plasma osmolality was elevated maximally to 344±7.1mOsm/L and the urine volume was maintained well during bypass. A hypertonic mannitol solution was effective in maintaining the CPAH during and after bypass, but was not effective in minimizing the reduction in Ccr. When the mean arterial pressure during bypass was kept at 60mmHg, the carbon filling rates in glomeruli showed the favorable effects of mannitol upon renal function, but no effects were observed at a mean arterial pressure of 80mmHg.
In 11 patients who had undergone a bypass lasting more than 2hrs with mannitol infusions, the plasma osmolality reflected the serum mannitol level and reached 320±11.0mOsm/L at 150min of bypass. The mean urine volume was 5.0±3.3ml/min/M2 during the bypass, which was about 7 times as great as before the bypass. The Ccr increased during the first 30min of the bypass, but it fell to about one half of the initial value after 90min of the bypass. It was concluded that a hypertonic mannitol solution is effective in maintaining the RPF and urine volume during and after the bypass and that it also preserved the glomerular perfusion even at a low arterial pressure.
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