Abstract
Effects of antihypertensive treatments on ocular lesions were evaluated in spontaneously hypertensive (SHR) rats with streptozotocin (STZ)-induced diabetes mellitus. STZ treatment induced ocular lesions such as narrowing of retinal arterioles, caliber irregularity, papilledema and cataracta in these rats. Enalapril, ramipril and arotinolol decreased blood pressure (BP) and prevented the progress of ocular lesions. Nisoldipine tended to decrease blood glucose (BG) and prevented the progress of ocular lesions. Therefore, antihypertensive treatments were shown to be effective in preventing the progress of ocular lesions in hypertensive rats with diabetes mellitus. Hypertension, as well as high BG, was suggested to play an important role in inducing ocular lesions.
