The Therapeutic Effects of Several Anti-hypertensive Drugs and Diet on M-SHRSP

Changes in Life Spans, Blood Pressures, Plasma Hormones, Fundus Oculi and Internal Organs

Abstract

M-SHRSP, a rat strain considered as a suitable model for the study of juvenile human malignant hypertension, were subjected to a variety of treatments for hypertension. The results showed the following: 1) It should be possible, through suitable diets appropriately combined with the administration of a selection of anti-hypertensive agents involving different mechanisms, to develop marked preventive and therapeutic results even for extremely malignant hypertensive rats such as M-SHRSP. 2) SQ 29852 seems to be a better drug than captopril. 3) In malignant hypertension, factors other than the high blood pressure itself, also, seem to play a role in the occurrence of such vascular lesions as angionecrosis.