Abstract
Abana is a herbomineral medicinal preparation with a property of down-regulation of beta-adrenergic receptors. A double-blind, parallel group study was conducted in 43 Indian men and women suffering from hypertension to evaluate the antihypertensive effect of Abana and compare it with that of methyldopa (M-DOPA). Twenty-one patients received 800mg tds of Abana and 22 patients received 250mg tds of MDOPA for 4 weeks. Blood pressure and pulse rate were recorded at weekly intervals. Relevant clinical and biochemical investigations were carried out before and after treatment.
In patients treated with Abana, there was a significant fall both in systolic B.P. (from 167±3.73 to 145±6.11mmHg) and in diastolic B.P. (from 110±1.86 to 91±3.04mmHg) at the end of 4 weeks. Similarly in patients treated with M-DOPA, systolic blood pressure was significantly reduced from 165±4.92 to 146±4.9mmHg and diastolic blood pressure was reduced from 106±2.74 to 96±2.67mmHg after 4 weeks. The onset of antihypertensive effect was earlier and there was a higher percentage of responders (80%) in the Abana-treated group. None of the patients had clinically or biochemically significant side-effects. The results of this study suggest that therapy with Abana proved highly effective in hypertensive patients.
