Plasma Lipid Profile in Obese Children and in Children with Hereditary Predisposition to Coronary Heart Disease

Abstract

This study examined risk factors for coronary disease and plasma triglycerides, total cholesterol, HDL, LDL cholesterol (C), Apo A-1, and Apo B lipoprotein levels in obese children (n=107) aged 9-12 years old and in children (n=64) hereditarily predisposed to coronary heart disease (CHD). In the latter group, children's fathers had a history of MI before 50 years of age.
A control group of 30 children was also studied, and the plasma lipid profile was investigated in 35 fathers with premature myocardial infarction. Seventy-five percent of the obese children and 60% of the children hereditarily predisposed to CHD had three or more coronary artery disease risk factors. Plasma HDL-C (p<0.001), LDL-C (p<0.001-p<0.05, respectively), Apo A-1 (p<0.001), and Apo B (p<0.001) levels were different in both groups compared with controls.