1967 Volume 8 Issue 2 Pages 148-155
Reninlike activity in rat kidneys was measured using a simple but reliable procedure that involved giving saline extracts of portions of renal tissues into the sensitized assay rats.
(1) Clamping one renal artery caused an increased concentration of renin in the clamped kidney and a fall in the contralateral untouched kidney.
(2) Coarctation of aorta above the main renal artery induced marked hypertension, but did not result in an increase in renin concentration of the kidneys.
(3) Renin content was definitely diminished in kidneys of rats with adrenal regeneration hypertension.
(4) In rats with neurogenic hypertension the amount of pressor material in kidneys was within the normal range.
High blood pressure may, therefore, be maintained independently of an increase in renin concentration of the kidneys.
