Hemagglutination of Formalin Preserved Erythrocytes Treated with Tannic Acid and Sensitized with Streptokinase-Streptodoranase (Varidase)

Abstract

Hemagglutination of formalin preserved human group O erythrocytes treated with tannic acid and sensitized with streptokinase-steptodornase (Varidase) were devised by us and investigated in 183 sera of patients suffering from rheumatic fever, acute glomerulonephritis, scarlet fever and chronic tonsillitis etc. High titers were often observed in these poststreptococcal sequelae and titers were commonly low in apparently healthy persons. The titers of the hemagglutination (anti-SK-SD) correlated with that of Todd units of antistreptolysin O, but usually higher than the latter.
It may be useful as one of the serological reactions for the supporting evidence of preceding streptococcal infection in guidance for the diagnosis of rheumatic fever.