Effects of Chondroitin Sulfates on Serum Lipids and Hexosamines in Atherosclerotic Patients with Special Reference to Thrombus Formation Time

Kenjiro IZUKA; Katsumi MURATA; Koji NAKAZAWA; Kazuko OKUBO; Yoshio OSHIMA

doi:10.1536/ihj.9.453

Effects of Chondroitin Sulfates on Serum Lipids and Hexosamines in Atherosclerotic Patients

with Special Reference to Thrombus Formation Time

Kenjiro IZUKA, Katsumi MURATA, Koji NAKAZAWA, Kazuko OKUBO, Yoshio OSHIMA

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Keywords: Acid mucopolysaccharides, Chondroitin sulfates A, B and C, Glucosamine, Galactosamine, Cholesterol, Thrombosis

JOURNAL FREE ACCESS

1968 Volume 9 Issue 5 Pages 453-460

DOI https://doi.org/10.1536/ihj.9.453

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Abstract

Long term effects of chondroitin sulfates A and C on the lipid and hexosamine levels were studied for 22 weeks in the patients with atherosclerosis. Chondroitin sulfates A and C both kept serum cholesterol levels low in the patients in comparison with the controls during the course of treatment.
Short term effects of chondroitin sulfate C injected intravenously on the thrombus formation time were also studied in the patients by Chandler's method in connection with thrombogenic causes of atherosclerosis. The prolongation of thrombus formation time was observed at 30 and 60min. after the injection of the substance.

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