The Influence of Synthetic Bone Mineral to Bone Formation

Abstract

Dental implant is an effective treatment modality to restore esthetic loss and masticatory dysfunctions. However, at least three to six months healing period following implant surgery is necessary. This healing period is burden for the patients, especially with a broad edentulous area and may decrease their quality of life. Therefore, shortening the healing period and accelerating prosthetic rehabilitation is clinically important. We speculate periimplant bone may be improved by systematic approaches such as use of osteoporosis supplement promoting bone metabolism. As a preliminary step, an animal pilot study was conducted to confirm whether intake of the synthetic bone mineral (SBM) is effective in bone formation.
To confirm whether intake of a supplement developed for osteoporosis, SBM, is effective in bone formation.
Twelve female Wister rats, 20-week-old were randomly assigned to receive a　 standardized diet with SBM (n=6) or without SBM (n=6, control).
After 8 weeks, right and left femur were extracted form the rat under CO₂ inhalation and bone mineral density (BMD) and bone flexure strength were determined. Between group differences in bone mechanical strength and BMD at 28 weeks old were analyzed by Mann‒Whitney Utest.
BMD was significantly higher for the Diet with SBM group at compared to the Diet without SBM group (P<0.05). Pull-out strength was also significantly increased than the Diet without SBM group (P<0.05).
Within the imitations, this study indicates that SBM could be effective in bone formation.