Abstract
To the best of our knowledge, only four patients with chronic expanding hematoma (CEH) of the digits have been reported. Herein, along with other literature reviews, we describe a case with CEH of the thumb. An 81-year-old woman presented to our hospital with an enlarged subcutaneous mass in the thumb and underwent en bloc resection. Based on the clinical and histopathological findings, the patient was diagnosed with CEH. She had no remarkable history of trauma, but was taking antiplatelet drugs. These drugs may contribute to the pathogenesis of CEH of the thumb. We examined the clinical characteristics of this condition by reviewing previously reported cases and found no clear bias, including age of onset, male-to-female ratio, and left–right differences. The treatment strategy and recurrence rates of this disease remain controversial; however, in this case, the patient’s condition resolved without any recurrence after the mass was surgically resected en bloc.

(a) To excise skin that is expanded and includes a punch biopsy scar, a spindle-shaped incision line is designed on the skin. (b) Macroscopic features of the resected specimen. (c) Macroscopic features of the resected specimen immediately after surgery: the wound is temporally sutured and closed. (d) Superficial layer of the skin. (e) Margin.