TOXICITY OF PHTHALODINITRILE AND TETRACHLOROPHTHALODINITRILE

I. ACUTE TOXICITY IN MICE

Abstract

An acute toxicity of phthalodinitrile and tetrachlorophthalodinitrile in mice was investigated. Isomers of the both compounds were examined and significant differences were noticed in their LD50 values as well as in the symptoms of acute intoxications. The respective intraperitoneal LD50 of o-, m-, and p-phthalodinitrile were 34.5, 481.3 and 698.6 mg/kg, and those of o-, m-, and p-tetrachlorophthalodinitrile were 66.4, 2.5 and 1581.3 mg/kg. From the results obtained, it was suggested that these compounds had different toxic properties.