Abstract
We accomplished the following three very important break-through 1) we established technology for Superproliferation of MSC and developed Automatic cell culture system, 2) we conducted pre-clinical tests in animal experiments designed for dental applications and 3) we participated and supported clinical research into actual treatment of periodontal disease.
We developed Automatic Cell Culture system for mesencymal stem cells(MSC) ‘YURIKAGO’ in 2007. The system has various characteristics 1) size is smaller than other system, 2) weight is lighter than other systems, 3) culture program is all automatic (culture, passage and harvest) and 4) we can proliferate MSC for the vast numbers required for treatment with having kept retention of multilineage differentiation potential. The key to this system is original MSC proliferation technology obtained by TWO CELLS that utilize basic Fibroblast Growth Factor(bFGF) that takes a few MSC and produces the vast numbers required for treatment. It is a wish that an intractable disease can be treated using our system and MSC.
