Role of sphingosine 1-phosphate signaling for the pathogenesis of autoimmune diseases

Tsuyoshi Iwasaki; Sachi Tsunemi; Sachie Kitano; Chieri Kanda; Masahiro Sekiguchi; Masayasu Kitano; Hajime Sano

doi:10.2492/inflammregen.31.175

Mini Review

Role of sphingosine 1-phosphate signaling for the pathogenesis of autoimmune diseases

Tsuyoshi Iwasaki, Sachi Tsunemi, Sachie Kitano, Chieri Kanda, Masahiro Sekiguchi, Masayasu Kitano, Hajime Sano

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Keywords: sphingosine 1-phospahte, FTY720, rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome

JOURNAL FREE ACCESS

2011 Volume 31 Issue 2 Pages 175-183

DOI https://doi.org/10.2492/inflammregen.31.175

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Abstract

Sphingosine 1-phosphate (S1P) acts as an extracellular mediator by binding to G protein- coupled receptors, regulating cell proliferation, angiogenesis and inflammation. FTY720 (FTY) is a high-affinity agonist for S1P receptors, inducing internalization of receptors, rendering the cells unresponsive to S1P. Here, we review the role of S1P signaling for the pathogenesis of autoimmune diseases and the therapeutic effects of FTY on autoimmune diseases.

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