Abstract
It is now widely accept that stem cell-like cancer cells, also known as cancer initiating cells (CIC), cancer stem cells or cancer propagating cells, in various types of cancers, including malignant glioma. Because it is likely that CICs proliferate indefinitely, express characteristics of tissue-specific stem cells exist, form tumor and are resistant to chemo- and radio-therapy, it is important to establish their purification methods, characterize them and find therapeutic ways. In this review, I will summarize recent progress about glioma initiating cell that is one of best CIC models.
