Immunomodulation of mesenchymal stem/stromal cells for the onset of cGVHD

Abstract

Mesenchymal stem/stromal cells (MSC) present in many tissues that are multipotent which can differentiate into several different cell types. Mesenchymal stem cells are alsobelieved to act on the inflammatory-immune reactions in the local to release humoral factors by integrating the tissue injury site. MSCs migrate to the damaged tissue site to involve in tissue repair when they administered exogenously. Communicating with the inflammatory microenvironment is an important part of this process. In recent years, it has been studied that the cellular and molecular mechanisms of interaction between MSC and the various participants in inflammation. Depending on their type and strength of the inflammatory stimulus, the MSC changes its role either for suppressive or inducible for the immune response. Here, we review the current paradigm about the immunomodulatory functions of MSCs in according with our recent finding of cGVHD animal model study.