Case Series of Pulmonary Tumor Embolism and Intravascular Lymphoma: Evaluation of the Usefulness of Pulmonary Microvascular Cytology

Takashi Ishiguro; Noboru Takayanagi; Yuri Baba; Naho Kagiyama; Takashi Miyamoto; Makoto Mutoh; Yoshihiko Shimizu; Yutaka Sugita

doi:10.2169/internalmedicine.55.6855

CASE REPORTS

Case Series of Pulmonary Tumor Embolism and Intravascular Lymphoma: Evaluation of the Usefulness of Pulmonary Microvascular Cytology

Takashi Ishiguro, Noboru Takayanagi, Yuri Baba, Naho Kagiyama, Takashi Miyamoto, Makoto Mutoh, Yoshihiko Shimizu, Yutaka Sugita

Author information

Takashi Ishiguro
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Noboru Takayanagi
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Yuri Baba
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Naho Kagiyama
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Takashi Miyamoto
Department of Cardiovascular Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Makoto Mutoh
Department of Cardiovascular Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Yoshihiko Shimizu
Department of Pathology, Saitama Cardiovascular and Respiratory Center, Japan
Yutaka Sugita
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan

Keywords: pulmonary microvascular cytology, pulmonary tumor embolism, pulmonary hypertension, intravascular lymphoma, pulmonary wedge aspiration cytology

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 18 Pages 2679-2684

DOI https://doi.org/10.2169/internalmedicine.55.6855

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Abstract

Pulmonary tumor embolism (PTE) and intravascular lymphoma cause rapidly progressive deterioration and an antemortem diagnosis is difficult. The usefulness of pulmonary microvascular cytology (PMC) in the diagnosis of these disorders has been reported in sporadic case reports. We retrospectively evaluated the records of 7 patients with tumor cells in the pulmonary microvasculature (4 with PTE and 3 with malignant lymphoma) who underwent pulmonary microvascular cytology. Two of the 4 patients with PTE and 2 of the 3 patients with malignant lymphoma (all 3 had intravascular metastasis) had positive PMC results. These findings suggested that PMC may be useful in the diagnosis of these disorders.

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