Desquamative Interstitial Pneumonia with Progressive Pulmonary Fibrosis

Takuhide Utsunomiya; Yoshiaki Kinoshita; Masayo Yoshimura; Yohei Koide; Kenji Wada; Yusuke Ueda; Yuji Yoshida; Hisako Kushima; Satoshi Nimura; Hiroshi Ishii

doi:10.2169/internalmedicine.1802-23

This article has now been updated. Please use the final version.

Desquamative Interstitial Pneumonia with Progressive Pulmonary Fibrosis

Takuhide Utsunomiya, Yoshiaki Kinoshita, Masayo Yoshimura, Yohei Koide, Kenji Wada, Yusuke Ueda, Yuji Yoshida, Hisako Kushima, Satoshi Nimura, Hiroshi Ishii

Author information

Takuhide Utsunomiya
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Yoshiaki Kinoshita
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Masayo Yoshimura
Department of Pathology, Fukuoka University Chikushi Hospital, Japan
Yohei Koide
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Kenji Wada
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Yusuke Ueda
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Yuji Yoshida
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Hisako Kushima
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan
Satoshi Nimura
Department of Pathology, Fukuoka University Chikushi Hospital, Japan
Hiroshi Ishii
Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan

Keywords: desquamative interstitial pneumonia, nintedanib, progressive pulmonary fibrosis, antifibrotics

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1802-23

DOI https://doi.org/10.2169/internalmedicine.1802-23

The final version of this article is now available: Vol. 63 (2024), No. 1 pp. 107-111

Details

Abstract

A 70-year-old man who smoked was referred to our hospital because of progressive cough and dyspnea. Radiologic images showed ground-glass attenuation predominantly in the lower lung lobes. A surgical lung biopsy was performed, and a diagnosis of desquamative interstitial pneumonia (DIP) was made. The patient's symptoms improved with smoking cessation and steroid treatment, but the ground-glass attenuation did not completely resolve. At 10 years after the diagnosis, the fibrotic lesions deteriorated and treatment with nintedanib was subsequently initiated. Careful observation is needed in patients with DIP whose lung involvement does not completely improve with initial treatment.

Corresponding author