Necrotizing Myelopathy Associated with Hepatocellular Carcinoma

Hiroyasu MISUMI; Hiromi ISHIBASHI; Kazutoshi KANAYAMA; Wataru KAJIYAMA; Hideyuki NOMURA; Takuya SUGIMOTO; Kaichiro HIROSHIGE; Yoshiyuki NIHO

doi:10.2169/internalmedicine1962.27.333

Hiroyasu MISUMI, Hiromi ISHIBASHI, Kazutoshi KANAYAMA, Wataru KAJIYAMA, Hideyuki NOMURA, Takuya SUGIMOTO, Kaichiro HIROSHIGE, Yoshiyuki NIHO

Author information

Hiroyasu MISUMI
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Hiromi ISHIBASHI
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Kazutoshi KANAYAMA
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Wataru KAJIYAMA
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Hideyuki NOMURA
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Takuya SUGIMOTO
The Second Department of Pathology, Faculty of Medicine, Kyushu University
Kaichiro HIROSHIGE
Fukuoka Saiseikai Hospital
Yoshiyuki NIHO
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University

Keywords: Necrotizing myelopathy, Hepatocellular carcinoma, Hepatoma, Paraneoplastic syndrome

JOURNAL FREE ACCESS

1988 Volume 27 Issue 3 Pages 333-336

DOI https://doi.org/10.2169/internalmedicine1962.27.333

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Abstract

A 43-year-old Japanese male with hepatocellular carcinoma suddenly developed paraplegia. The spinal cord signs first progressed rapidly but then gradually subsided. The patient died of hepatic failure ten months later. The autopsy disclosed cavitation and softening of the spinal cord from the level of C6 to T10, a characteristic of necrotizing myelopathy. Neither local nor apparent systemic causes to explain the spinal cord lesion were disclosed at the autopsy. This seems to be the first documented rare paraneoplastic syndrome, associated with hepatocellular carcinoma.

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