Clinical Significance of Serum Guanase Activity in Various Liver Diseases

Gohshi SHIOTA; Junko FUKADA; Toshiro ITO; Masamichi TSUKIZAWA; Minoru YAMADA; Masanori SATO

doi:10.2169/internalmedicine1962.28.22

Gohshi SHIOTA, Junko FUKADA, Toshiro ITO, Masamichi TSUKIZAWA, Minoru YAMADA, Masanori SATO

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Keywords: Serum guanase activity, Liver disease, Amino-transferases, Liver damage, Aminotransferase-to-guanase ratios

JOURNAL FREE ACCESS

1989 Volume 28 Issue 1 Pages 22-24

DOI https://doi.org/10.2169/internalmedicine1962.28.22

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Abstract

Serum guanase activity was measured using a sensitive colorimetric method in patients with liver diseases. Guanase activity was correlated with GPT, GOT in acute viral hepatitis and chronic hepatitis, however, in liver cirrhosis and hepatocellular carcinoma it was correlated with total bilirubin as well as aminotransferases. In addition, the GPT-to-guanase ratio differed chronic hepatitis from liver cirrhosis. These findings suggest that determination of guanase and aminotransferases is useful in differentiation of liver diseases as well as assessing liver damage.

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