A Study of the Clinical Significance of Lipoprotein (a) in Nephrotic Syndrome

Tadayoshi TAKEGOSHI; Chikashi KITOH; Toshihiro HABA; Jun-ichi HIRAI; Takanobu WAKASUGI; Takashi SAGA; Yoshikiyo YAMAZAKI; Hiroshi MABUCHI

doi:10.2169/internalmedicine1962.30.21

Tadayoshi TAKEGOSHI, Chikashi KITOH, Toshihiro HABA, Jun-ichi HIRAI, Takanobu WAKASUGI, Takashi SAGA, Yoshikiyo YAMAZAKI, Hiroshi MABUCHI

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Keywords: Atherosclerosis, HyperLp(a)aemia

JOURNAL FREE ACCESS

1991 Volume 30 Issue 1 Pages 21-25

DOI https://doi.org/10.2169/internalmedicine1962.30.21

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Published: 1991 Received: December 21, 1989 Available on J-STAGE: March 27, 2006 Accepted: September 18, 1990 Advance online publication: - Revised: -
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Date of correction: March 27, 2006 Reason for correction: - Correction: ABSTRACT Details: Wrong : Lipoprotein (Lp)(a) concentrations were measured in eight patients with nephrotic syndrome in the age range of 8 to 69 yrs. Mean (±SE) levels of serum Lp(a) were elevated in the nephrotic patients compared to controls (76.5±19.7 vs 18.6±0.9 mg/dl, p<0.001). After treatment with prednisolone, Lp(a) concentrations were decreased from 85.2±21.6 to 42.2±14.0 mg/dl. During the treatment, serum total cholesterol showed a negative correlation with serum albumin concentration. However, no correlation was noted between Lp(a) and serum albumin concentration. There were no significant correlations between Lp(a) and other lipoprotein lipid and apolipoprotein levels. It was concluded that hyperLp(a) aemia may be an independent risk factor in the development of premature atherosclerosis in patients with nephrotic syndrome.
Right : Lipoprotein (Lp)(a) concentrations were measured in eight patients with nephrotic syndrome in the age range of 8 to 69 yrs. Mean (±SE) levels of serum Lp(a) were elevated in the nephrotic patients compared to controls (76.5±19.7 vs 18.6±0.9 mg/dl, p<0.001). After treatment with prednisolone, Lp(a) concentrations were decreased from 85.2±21.6 to 42.2±14.0 mg/dl. During the treatment, serum total cholesterol showed a negative correlation with serum albumin concentration. However, no correlation was noted between Lp(a) and serum albumin concentration. There were no significant correlations between Lp(a) and other lipoprotein lipid and apolipoprotein levels. It was concluded that hyperLp(a) aemia may be an independent risk factor in the development of premature atherosclerosis in patients with nephrotic syndrome.

Date of correction: March 27, 2006 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Lipoprotein (Lp)(a) concentrations were measured in eight patients with nephrotic syndrome in the age range of 8 to 69 yrs. Mean (±SE) levels of serum Lp(a) were elevated in the nephrotic patients compared to controls (76.5±19.7 vs 18.6±0.9 mg/dl, p<0.001). After treatment with prednisolone, Lp(a) concentrations were decreased from 85.2±21.6 to 42.2±14.0 mg/dl. During the treatment, serum total cholesterol showed a negative correlation with serum albumin concentration. However, no correlation was noted between Lp(a) and serum albumin concentration. There were no significant correlations between Lp(a) and other lipoprotein lipid and apolipoprotein levels. It was concluded that hyperLp(a) aemia may be an independent risk factor in the development of premature atherosclerosis in patients with nephrotic syndrome.

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